Impaired long‐term potentiation–like plasticity of the trigeminal blink reflex circuit in Parkinson's disease
Identifieur interne : 003387 ( Main/Exploration ); précédent : 003386; suivant : 003388Impaired long‐term potentiation–like plasticity of the trigeminal blink reflex circuit in Parkinson's disease
Auteurs : Fortunato Battaglia [États-Unis] ; Maria Felice Ghilardi [États-Unis] ; Angelo Quartarone [Italie] ; Sergio Bagnato [Italie] ; Paolo Girlanda [Italie] ; Mark Hallett [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Blinking (physiology), Dose-Response Relationship, Radiation, Electric Stimulation (methods), Female, Functional Laterality, Humans, LTP, Long-Term Potentiation (physiology), Male, Middle Aged, Nervous system diseases, Palpebral reflex, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Potentiation, Reaction Time (physiology), Reaction Time (radiation effects), Synaptic plasticity, Trigeminal Nerve (physiopathology), Trigeminal Nerve (radiation effects), Trigeminal nerve, blink reflex.
- MESH :
- methods : Electric Stimulation.
- pathology : Parkinson Disease.
- physiology : Blinking, Long-Term Potentiation, Reaction Time.
- physiopathology : Parkinson Disease, Trigeminal Nerve.
- radiation effects : Reaction Time, Trigeminal Nerve.
- Aged, Analysis of Variance, Dose-Response Relationship, Radiation, Female, Functional Laterality, Humans, Male, Middle Aged.
Abstract
We investigated the hypothesis that Parkinsons's disease (PD) is associated with abnormal plasticity of the neuronal circuits mediating blink reflex. We induced long‐term potentiation (LTP)‐like plasticity in trigeminal wide dynamic range neurons of the blink reflex circuit by pairing an high‐frequency train of electrical stimuli over the right supraorbital nerve (SO) coincident with the R2 response elicited by a preceding SO stimulus. The facilitation of the R2 response after the induction protocol was markedly decreased in patients relative to controls. Treatment with dopaminergic drugs normalized the LTP‐like plasticity of the R2 response. We conclude that nigrostriatal denervation disrupts LTP‐like plasticity in the trigeminal reflex circuit. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21138
Affiliations:
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Le document en format XML
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We induced long‐term potentiation (LTP)‐like plasticity in trigeminal wide dynamic range neurons of the blink reflex circuit by pairing an high‐frequency train of electrical stimuli over the right supraorbital nerve (SO) coincident with the R2 response elicited by a preceding SO stimulus. The facilitation of the R2 response after the induction protocol was markedly decreased in patients relative to controls. Treatment with dopaminergic drugs normalized the LTP‐like plasticity of the R2 response. We conclude that nigrostriatal denervation disrupts LTP‐like plasticity in the trigeminal reflex circuit. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Maryland</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Battaglia, Fortunato" sort="Battaglia, Fortunato" uniqKey="Battaglia F" first="Fortunato" last="Battaglia">Fortunato Battaglia</name></region><name sortKey="Ghilardi, Maria Felice" sort="Ghilardi, Maria Felice" uniqKey="Ghilardi M" first="Maria Felice" last="Ghilardi">Maria Felice Ghilardi</name><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></country><country name="Italie"><noRegion><name sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name></noRegion><name sortKey="Bagnato, Sergio" sort="Bagnato, Sergio" uniqKey="Bagnato S" first="Sergio" last="Bagnato">Sergio Bagnato</name><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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